Read this Medication Guide carefully before you start using WELLBUTRIN XL and each PATIENT & CAREGIVER EDUCATION. Immediate release tabletsmg, mg. What does bupropion do? Brand Names: US. Aplenzin; Forfivo XL; Wellbutrin SR; Wellbutrin XL. Brand Names: Canada Bupropion is an antidepressant medication that is now also used in smoking cessation. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessatio