National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology Results of the CATIE Study. The CATIE (Clinical Antipsychotic Trials for Intervention Effectiveness) Schizophrenia Trial was designed to examine fundamental issues about The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) PhaseSchizophrenia trial compared the effectiveness of one typical and four atypical The Clinical Antipsychotic Tri