D Aled ReesThree principal characteristics of the pathophysiology of polycystic ovary syndrome (PCOS) have been identified to date: an interaction between reproductive dysfunction and metabolic disorders, high familial aggregation and heritability, and a substantial contribution of environmental factors KEY POINTS. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. update on the pathophysiology, diagnosis, and clinical features of PCOS, and discuss the needs and priorities