When approaching a critical appraisal manuscript there are many factors that need consideration before a manuscript is ready for publication. A stepwise approach, we find, works well. The . What is critical appraisal? Balanced assessment of the reliability/validity, significance/relevance, strengths/weaknesses of a study. Assessment of both research process and results. Negative . “Critical appraisal is the process of systematically examining research evidence to assess its validity, results, an